Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease.

Fanny M Elahi,Gabe Marx,Yann Cobigo,Adam M Staffaroni,John Kornak,Duygu Tosun,Adam L Boxer,Joel H Kramer,Bruce L Miller,Howard J Rosen

NeuroImage: Clinical（2017）

引用 39|浏览9

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摘要

•We show longitudinal change in white matter in frontotemporal lobar degeneration (FTLD) and Alzheimer’s disease (AD).•We use diffusion tensor imaging (DTI) to quantify rate of white matter degeneration in FTLD and AD.•In preparation for clinical trials, utility of longitudinal DTI as surrogate marker of therapeutic efficacy is investigated.•We produce sample sizes based on rate of change in DTI metrics in the three canonical subtypes of FTLD and AD.

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关键词

Longitudinal,DTI,White matter integrity,Sample size,Clinical trial,FTD,AD,Behavioral variant FTD,Primary progressive aphasia

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