Monocyte chemoattractant protein 1 released from macrophages induced by hepatitis C virus promotes monocytes migration.

•MCP-1 were up-regulated in THP-1 and macrophages induced by HCV infection.•HCV infected macrophages promote the migration of monocytes.•Long-term of HCV infection induced apoptosis of macrophages.•The morphology of Huh7 cells co-cultured with monocyte/macrophages were greatly changed.