Carbon dioxide elimination by cardiomyocytes: a tale of high carbonic anhydrase activity and membrane permeability.
Acta physiologica (Oxford, England)(2017)
摘要
Life as a multicellular organism requires a heart with a coordinated contractile activity that must never cease, and in this regard, it is very much like the brain with a high mass-specific 'resting' metabolic rate. To maintain this constant activity requires a high rate of oxygen consumption and resultant carbon dioxide generation and, pari passu, the rapid exchange of large amounts of these gases with capillary blood. While oxygen has been far more the focus of the two gases in cardiac physiology, the work of Arias-Hidalgo et al (1) in this issue of the journal offers new insights and better understanding of how CO2 uniquely traverses its path from production in the mitochondria to the capillary blood, and does so with much smaller driving gradients than necessary for oxygen. This article is protected by copyright. All rights reserved.
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