Novel ex vivo protocol using porcine vagina to assess drug permeation from mucoadhesive and colloidal pharmaceutical systems.

Maíra N Pereira,Thaiene A Reis,Breno N Matos,Marcílio Cunha-Filho,Taís Gratieri,Guilherme M Gelfuso

Colloids and Surfaces B: Biointerfaces（2017）

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摘要

•Ex vivo vertical model, where formulations are placed in hung porcine vaginas.•Proposed new method was capable of differentiating formulations performances.•Porcine mucosa histological structures were preserved during new assay.•Method is reliable for approaching physiological situation in comparative studies.

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关键词

Hung vagina,Ketoconazole,Mucoadhesive systems,Nanoparticle,Permeation protocol,Porcine vaginal mucosa

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