Induction, treatment and prevention of eczema vaccinatum in atopic dermatitis mouse models.

Hagit Achdout,Shlomo Lustig,Tomer Israely,Noam Erez,Boaz Politi,Hadas Tamir,Ofir Israeli,Trevor Waner,Sharon Melamed,Nir Paran

Vaccine（2017）

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摘要

•Established robust mouse models of severe atopic dermatitis and eczema vaccinatum.•Effective treatment of severe eczema vaccinatum with antibodies and Cidofovir.•MVA immunization of atopic dermatitis mice is T cell dependent.•CD4+ T cells are required for protection against eczema vaccinatum by MVA.

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关键词

EV,AD,DNFB,ECTV,CDV,p.i.,VACV,TEWL,MVA,VIG,α-VACV,s.c.,i.n.,i.m.,H&E,BRP,MTTD,PRNT,d,h.p.i

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