Live imaging of the innate immune response in neonates reveals differential TLR2 dependent activation patterns in sterile inflammation and infection.

Melanie Lalancette-Hébert,Joel Faustino,Sai Sampath Thammisetty,Sophorn Chip,Zinaida S Vexler,Jasna Kriz

Brain, Behavior, and Immunity（2017）

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摘要

•TLR2 is highly expressed in early postnatal brain under physiological conditions.•Systemic LPS caused a robust induction of TLR2 in neonatal brain.•Acute sterile injury including stroke in neonates does not induce TLR2.•TLR2 response in neonates is mediated by resident microglia/macrophages.

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关键词

Microglia,TLR2,Biophotonic/bioluminescence imaging,Neonate,LPS,tMCAO,IL-1β

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