Predictive and prognostic value of phosphorylated c-KIT and PDGFRA in advanced non-small cell lung cancer harboring ALK fusion

    Fengnan Wang
    Fengnan Wang
    Xiaodong Lin
    Xiaodong Lin
    Dongyun He
    Dongyun He

    Oncology letters, Volume 17, Issue 3, 2019, Pages 3071-3076.

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    Keywords:
    anaplastic lymphoma kinaseintrinsic resistancemast/stem cell growth factor receptor Kitnon-small cell lung cancerplatelet-derived growth factor receptor α

    Abstract:

    Secondary gene amplification leads to tyrosine kinase inhibitor resistance in anaplastic lymphoma kinase (ALK) fusion-positive advanced non-small cell lung cancer (NSCLC). The presence of the 4q12 amplicon causes the activation of downstream mast/stem cell growth factor receptor Kit (c-Kit) or platelet-derived growth factor receptor α (P...More

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