Features Of Ebola Virus Disease At The Late Outbreak Stage In Sierra Leone: Clinical, Virological, Immunological, And Evolutionary Analyses
JOURNAL OF INFECTIOUS DISEASES(2017)
摘要
We performed Ebola virus disease diagnosis and viral load estimation for Ebola cases in Sierra Leone during the late stage of the 2014-2015 outbreak (January-March 2015) and analyzed antibody and cytokine levels and the viral genome sequences. Ebola virus disease was confirmed in 86 of 1001 (9.7%) patients, with an overall case fatality rate of 46.8%. Fatal cases exhibited significantly higher levels of viral loads, cytokines, and chemokines at late stages of infection versus early stage compared with survivors. The viruses converged in a new clade within sublineage 3.2.4, which had a significantly lower case fatality rate.
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关键词
ebola virus disease, Sierra Leone, clinical features, immunological characteristics, evolutionary analyses
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