A Time-to-Event Model for Acute Kidney Injury after Reduced-Intensity Conditioning Stem Cell Transplantation Using a Tacrolimus- and Sirolimus-based Graft-versus-Host Disease Prophylaxis

•AKI is frequent in the context of sirolimus- and tacrolimus-based GVHD prophylaxis after RIC allo-HSCT.•The new KDIGO classification system to define AKI appears to be useful in predicting outcome and should be prospectively explored in the allo-HSCT setting.•Parametric longitudinal and time-to-event data analysis allowed us to identify the association of tacrolimus exposure and the development of AKI in RIC allo-HSCT.•This study presents the first predictive model describing time to AKI as a function of tacrolimus drug concentration.