Glucagon-like peptide-2 promotes gallbladder refilling via a TGR5-independent, GLP-2R-dependent pathway

Bernardo Yusta,Dianne Matthews,Grace B. Flock,John R. Ussher,Brigitte Lavoie,Gary M. Mawe,Daniel J. Drucker

Molecular Metabolism（2017）

引用 38|浏览8

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摘要

•GLP-2 promotes gallbladder filling in mice.•The actions of GLP-2 on the gallbladder are absent in Glp2r−/− mice.•GLP-2 promotes gallbladder filling independent of Tgr5.•The Glp2r is expressed in the murine and human gallbladder.•GLP-2R-stimulated calcium flux in the gallbladder is blocked by tetrodotoxin.

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关键词

Bile acids,Gallbladder,Enteroendocrine,Glucagon-like peptide,TGR5,GLP-1,GLP-2

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