Endurance exercise per se reduces the cardiovascular risk marker t-PA antigen in healthy, younger, overweight men

•Tissue plasminogen activator (t-PA) antigen is a marker of cardiovascular risk.•Exercise interventions associated with weight loss reduce t-PA antigen.•The effect of exercise per se, without weight loss, on t-PA antigen is unknown.•We examine effects of 12weeks of exercise per se on t-PA in overweight men.•Endurance training per se reduces t-PA antigen in healthy overweight men.