Second generation DNA-encoded dynamic combinatorial chemical libraries.

Francesco V Reddavide,Meiying Cui,Weilin Lin,Naiqiang Fu,Stephan Heiden,Helena Andrade,Michael Thompson,Yixin Zhang

CHEMICAL COMMUNICATIONS（2019）

引用 38|浏览7

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摘要

We present a DNA-encoded chemical library, which allows dynamic selection followed by ligation of the encoding strands. As a chemical approach to mimic the genetic recombination process of adaptive immunity, the technology led to an enhanced enrichment factor and signal-to-noise ratio compared to static libraries.

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