Anabolic-androgen steroids effects on bioenergetics responsiveness of synaptic and extrasynaptic mitochondria.

Randhall B Carteri,Afonso Kopczynski,Lizia Nardi Menegassi,Marcelo Salimen Rodolphi,Nathan Ryzewski Strogulski,Luis Valmor Portela

Toxicology Letters（2019）

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摘要

•Synaptic and extrasynaptic mitochondria display distinct response to anabolic steroids.•Nandrolone impaired mitochondrial Ca2+ control and membrane potential.•Nandrolone increased mitochondrial H2O2 production and Tau hypersphosphorylation.•Testosterone positively modulated mitochondrial bioenergetics respiratory outcomes.•Anabolic steroids did not impair spatial memory.

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关键词

Testosterone,Nandrolone decanoate,Synaptic,Extrasynaptic,Ca2+ handling,Mitochondrial bioenergetics,Memory

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