Microscopic Characterization Of Membrane Insertion And Dynamics Of An Isoprenoid Lipid
BIOPHYSICAL JOURNAL(2017)
摘要
Bacterial cell wall synthesis requires the transport of peptidoglycan components across cell membrane via the carrier lipid, undecaprenyl pyrophosphate (UPP). The essential role of UPP in bacterial cell growth renders itself a valuable drug target for antimicrobial treatments (e.g. direct binding by bacitracin, nisin, and clausin) in addition to its metabolic enzymes. After synthesized by a soluble enzyme, UPP needs to be incorporated into the membrane before entering the cell-wall biosynthesis pathway.
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