Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

NATURE(2017)

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摘要
Depletion of malic enzyme 3 in pancreatic cancer cells that have a deletion of the gene for malic enzyme 2 selectively kills the cells, suggesting that the enzyme might represent a therapeutic target for this subset of cancers.
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关键词
Pancreatic cancer,Target identification,Science,Humanities and Social Sciences,multidisciplinary
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