A High-Fat/High-Sucrose Diet Induces WNT4 Expression in Mouse Pancreatic β-cells.

Yayoi Kurita,Tsuyoshi Ohki,Eri Soejima,Xiaohong Yuan,Satomi Kakino,Nobuhiko Wada,Toshihiko Hashinaga,Hitomi Nakayama,Junichi Tani,Yuji Tajiri,Yuji Hiromatsu,Kentaro Yamada,Masatoshi Nomura

The Kurume medical journal（2019）

引用 17|浏览24

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摘要

We demonstrated that the HF/HS diet-induced increase of WNT4 signaling in β-cells is involved in augmentation of glucose-induced insulin secretion and impaired β-cell proliferation. These results strongly indicate an essential role of WNT4 in the regulation of β-cell functions in mouse pancreatic islets.

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关键词

WNT4,high-fat/high-sucrose diet,insulin secretion,pancreatic islet,β-cell

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