Genomic characterization of hepatitis C virus transmitted founder variants with deep sequencing.
Infection, Genetics and Evolution(2019)
摘要
Transfer of hepatitis C virus (HCV) infection from a donor to a new recipient is associated with a bottleneck of genetic diversity in the transmitted viral variants. Existing data suggests that one, or very few, variants emerge from this bottleneck to establish the infection (transmitted founder [T/F] variants). In HCV, very few T/F variants have been characterized due to the challenges of obtaining early infection samples and of high throughput viral genome sequencing.
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关键词
Hepatitis C virus,Transmitted-founder virus,People who inject drugs,InC3 study,Next generation sequencing
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