RIG-I activating immunostimulatory RNA boosts the efficacy of anticancer vaccines and synergizes with immune checkpoint blockade.

Simon Heidegger, Diana Kreppel,Michael Bscheider,Florian Stritzke, Tatiana Nedelko,Alexander Wintges,Sarah Bek,Julius C Fischer,Theresa Graalmann,Ulrich Kalinke,Florian Bassermann,Tobias Haas,Hendrik Poeck

EBioMedicine（2019）

引用 33|浏览23

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摘要

Overall, our data demonstrate the potency of a novel combinatorial vaccination strategy combining RIG-I-driven immunization with CTLA-4 blockade to prevent and treat experimental melanoma. FUND: German Research Foundation (SFB 1335, SFB 1371), EMBO, Else Kröner-Fresenius-Foundation, German Cancer Aid, European Hematology Association, DKMS Foundation for Giving Life, Dres. Carl Maximilian and Carl Manfred Bayer-Foundation.

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关键词

Immuno-oncology,Innate immunity,RIG-I,Immune checkpoint inhibitors,Anti-cancer vaccine,Dendritic cells

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