Knockout of P2Y aggravates experimental autoimmune encephalomyelitis in mice via increasing of IL-23 production and Th17 cell differentiation by dendritic cells.

Jiang Zhang,Zhenlong Li,Xuefei Hu,Qiong Su,Cong He,Jing Liu,Hua Ren,Min Qian,Junling Liu,Shufang Cui,Wenzheng Jiang

Brain, Behavior, and Immunity（2017）

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摘要

•Knockout of P2Y12 receptor results in exacerbated EAE.•Th17 responses are enhanced in P2Y12-knockout EAE mice.•Deficiency of P2Y12 does not affect the differentiation of Th cell subgroups directly.•P2Y12-deficient DCs promote Th17 cell differentiation by increasing IL-23 production.

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关键词

EAE,DC,P2Y12,Knockout,Th17,IL-23

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