Straightforward Syntheses That Avoid Scrambling of meso-Substituted [28]Hexaphyrins

A two-step synthesis of meso-substituted [28]hexaphyrins in an aqueous medium was developed and optimized, and scrambling processes are avoided despite the use of a high acid concentration. The efficiency of this procedure relies on the nature of the starting material, and it can be extended to the straightforward preparation of unprecedented AB(2)C(2)D-[28]hexaphyrins bearing up to four different kinds of meso-appended aryl group.