P108 Novel LOXL2 selective small molecule inhibitors reduce cross-link formation and alter matrix properties in an in vitro fibroblastic foci model of IPF

Introduction: The lung tissue of patients with idiopathic pulmonary fibrosis (IPF) is characterised by dense collections of myofibroblasts and extracellular matrix (ECM) termed ‘fibroblastic foci’. Using a novel in vitro model of fibroblastic foci (Jones et al., AJRCCM 191;2015:A4912) we have characterised the formation of lysyl-oxidase (LOX) mediated collagen cross-links …