Class I lysine deacetylases promote glucocorticoid-induced transcriptional repression through functional interaction with LSD1

Nina M. Patrick, Chanel A. Griggs, Ali L. Icenogle, Maryam M. Gilpatrick,Vineela Kadiyala,Rosa Jaime-Frias,Catharine L. Smith

The Journal of Steroid Biochemistry and Molecular Biology（2017）

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摘要

•Lysine deacetylases (KDACs or HDACs) are required for glucocorticoid-mediated transcriptional repression in a gene-selective fashion.•KDACs promote transcriptional repression through suppression of LSD1 complex activity at selected target promoters.•Pharmacological modulation of KDACs or LSD1 in treatment of disease could significantly impact glucocorticoid-regulated transcription and alter cellular response.

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关键词

KDAC,KDACi,KAT,GR,VPA,NR,Dex,GAPDH,HDAC,HDACi,HAT,RT-qPCR,Ct,siRNA,LSD1,AR,CoREST,REST,NURD,SRC,ER,ChIP

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