Optimal Sequence of Local and EGFR-TKI Therapy for EGFR-mutant NSCLC with Brain Metastases Stratified by Number of Brain Metastases.

Eriko Miyawaki,Hirotsugu Kenmotsu,Keita Mori,Hideyuki Harada,Koichi Mitsuya,Nobuaki Mamesaya,Takahisa Kawamura,Haruki Kobayashi,Kazuhisa Nakashima,Shota Omori,Kazushige Wakuda,Akira Ono,Tateaki Naito,Haruyasu Murakami,Masahiro Endo,Yoko Nakasu,Yasuhiro Gon,Toshiaki Takahashi

International Journal of Radiation Oncology*Biology*Physics（2019）

引用 32|浏览118

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摘要

Upfront local therapy followed by EGFR-TKI is more effective than upfront EGFR-TKI for the survival of untreated patients harboring EGFR mutations with 1-4 BMs.

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关键词

Brain metastasis,Epidermal growth factor receptor mutations,Non-small cell lung cancer,Stereotactic radiosurgery,Tyrosine kinase inhibitors

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