Metabotropic glutamate receptor 2/3 density and its relation to the hippocampal neuropathology in a model of temporal lobe epilepsy in rats.

•Reduced mGluR2/3 binding in limbic regions at acute (2day) and latent periods (7day) after SE.•Increased mGluR2/3 binding in widely distributed brain areas at late latent phase (14day).•Reduced mGluR2/3 in stratum lacunosum moleculare during chronic epilepsy (42 & 84day).•MGluR 2/3 binding in CA1 region correlated negatively with cell loss in the hippocampus.