Identification of new p300 histone acetyltransferase inhibitors from natural products by a customized virtual screening method

Herein, we sought to discover new p300 HAT inhibitors from natural products by a customized structure-based virtual screening method. The natural compounds NP-2 (spinosine), NP-3 (palmatine), NP-9 (venenatine), and NP-15 (taxodione) were found to be potent p300 HAT inhibitors, of which IC50 values are 0.69 mu M, 1.05 mu M, 0.58 mu M, 4.85 mu M, respectively.