Cell-specific effects of Nox2 on the acute and chronic response to myocardial infarction

•ROS contribute to adverse cardiac remodeling after myocardial infarction (MI).•Nox2 is a major cardiac ROS source but with cell-specific effects.•Increased Nox2 in cardiomyocytes augments hypertrophy and fibrosis post-MI.•Increased Nox2 in endothelium has no significant effect on cardiac remodeling after MI.•Cardiomyocyte Nox2 may have the more important role in post-MI remodeling.