Parenteral adenoviral boost enhances BCG induced protection, but not long term survival in a murine model of bovine TB

Daryan A. Kaveh,M. Carmen Garcia-Pelayo, Paul R. Webb,Esen E. Wooff,Véronique S. Bachy,Philip J. Hogarth

Vaccine（2016）

引用 6|浏览17

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摘要

•Parenteral administration of Adenoviral boost improved BCG induced protection.•This improved protection associates with the induction of specific CD8+ IFN γ producers.•These CD8+ IFN γ producers are induced via the boosting of additional epitopes, sub-dominantly induced by BCG.

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关键词

BCG,Adenovirus,Prime-boost,Tuberculosis,Protection,Parenteral vaccination

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