Autopsy case of atypical type of alzheimer's disease clinically diagnosed as corticobasal degeneration]

A 60-year-old, right-handed man developed gait disturbance. He also had difficulty in dressing and demonstrated depressive status, but did not have memory impairment. He was diagnosed as having corticobasal degeneration (CBD) because of right cortical atrophy and contralateral movement disorder. He died at the age of 69. The pathological diagnosis was not CBD but Alzheimer's disease. The brain showed severe atrophy, especially in the right superior parietal lobe and postcentral gyrus. The cortical lesion was most marked in the right parietal lobe within the neocortex, and was more severe than that in the limbic area. Clinically this patient was highly suspected to have CBD. This case, however, is categorized into atypical Alzheimer's disease with a focal cortical syndrome.