Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease.

•Neurogranin, synaptosomal-associated protein-25, visinin-like protein 1, and chitinase-3-like protein 1 (YKL-40) are emerging cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease.•The emerging CSF biomarkers are elevated in autosomal-dominant Alzheimer's disease.•CSF synaptosomal-associated protein-25, visinin-like protein 1, and YKL-40 increase 15–19 years before estimated symptom onset.•The emerging CSF biomarkers predict Alzheimer's disease–related outcomes.•CSF biomarkers predict estimated years from symptom onset in autosomal-dominant Alzheimer's disease mutation carriers.