Next-Generation Immunohistochemical Stains: True Multiplex (Triple) Immunohistochemical Panel for the Identification of Metastatic Carcinoma in Cytology Effusions

Charalambos Solomides,Marluce Bibbo,Rossitza Draganova-Tacheva,Ruth Birbe,Phoebe Holmes,James Casey, Lauren Behman,Esteban Roberts,Larry Morrison

AMERICAN JOURNAL OF CLINICAL PATHOLOGY（2015）

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摘要

Cytologic examination of serous effusions is of paramount importance because the finding of malignant cells denotes advanced cancer. Immunocytochemical (IHC) methods are valuable tools to ascertain the presence and origin of metastatic tumors in effusions. Ber-EP4 (EP-Cam) is an epithelial marker commonly used to identify epithelial cells of non-mesothelial origin. Calretinin is a marker for mesothelial cells, and …

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