A reduced population of CD103+CD11b+ dendritic cells has a limited impact on oral Salmonella infection

Immunology Letters(2016)

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摘要
•Salmonella-infected mice with reduced mucosal CD103+CD11b+ DC have similar:.•Bacteria burden in intestinal tissues and spleen compared to infected controls.•Frequency of mucosal IFN-γ & IL-17-producing T cells relative to infected controls.•IL-6 and IL-17 concentration in whole tissue lysates.•Salmonella-specific serum IgG and IgM, relative to infected controls.•Overall, reduced mucosal CD103+CD11b+ DC has a limited impact on Salmonella burden.
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关键词
Dendritic cells,IRF4,Infection,Salmonella,CD103,Mesenteric lymph node
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