A Theoretical Lower Bound for Selection on the Expression Levels of Proteins.
GENOME BIOLOGY AND EVOLUTION(2016)
摘要
We use simple models of the costs and benefits of microbial gene expression to show that changing a protein's expression away from its optimum by 2-fold should reduce fitness by at least 0: 2 . P, where P is the fraction the cell's protein that the gene accounts for. As microbial genes are usually expressed at above 5 parts per million, and effective population sizes are likely to be above 10 6, this implies that 2-fold changes to gene expression levels are under strong selection, as N-e . s >> 1,where N-e is the effective population size and s is the selection coefficient. Thus, most gene duplications should be selected against. On the other hand, we predict that for most genes, small changes in the expression will be effectively neutral.
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关键词
gene expression levels,metabolic models,microbiology
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