Levodopa-Carbidopa Intestinal Gel In A Pediatric Parkinsonism-Plus Syndrome

In Parkinsonu0027s disease, levodopa-carbidopa intestinal gel (LCIG) is indicated in control of motor fluctuations, dyskinesias1 and non-motor symptoms. We here report the first case of LCIG pediatric use. Our patient presented with upper limb tremor at 6 months and subsequently with axial hypotonia, dysphagia and generalized dystonia. He did not achieve the milestones in psychomotor development: he could not stand, walk, nor manipulate objects; verbal production was never acquired. At 14 months, brain magnetic resonance was normal and cerebrospinal fluid examination showed low levels of homovanillic acid, neopterin and biopterin.This article is protected by copyright. All rights reserved.