Metastatic Clear-cell Renal Cell Carcinoma With a Long-term Response to Sunitinib: A Distinct Phenotype Independently Associated With Low PD-L1 Expression.

Solène-Florence Kammerer-Jacquet,Angelique Brunot,Mathilde Lefort,Sahar Bayat,Benoit Peyronnet,Gregory Verhoest,Romain Mathieu,Alexandra Lespagnol,Jean Mosser,Brigitte Laguerre,Alain Ravaud,Jean-Christophe Bernhard,Frantz Dupuis,Mokrane Yacoub,Marc-Antoine Belaud-Rotureau,Karim Bensalah,Nathalie Rioux-Leclercq

Clinical Genitourinary Cancer（2019）

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摘要

Primary tumor characteristics of LTRs were studied for the first time and demonstrated a different phenotype. Interestingly, they were characterized by low expression of PD-L1, suggesting a potentially lower impact of targeted immunotherapy in these patients.

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关键词

Checkpoint inhibitors,Kidney cancer,Long-term responders,Metastasis,PD-1

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