Infrared Autofluorescence, Short-Wave Autofluorescence And Spectral-Domain Optical Coherence Tomography Of Optic Disk Melanocytomas

AIM: To investigate the findings of infrared fundus autofluorescence (IR-AF) and spectral -domain optical coherence tomography (SD-OCT) in eyes with optic disc melanocytoma (ODM).METHODS: IR -AF findings and those of other ophthalmologic imaging examinations, including short wave autofluorescence (SW-AF), fluorescein angiography (FA), fundus color photography, and SD-OCT of 8 eyes of 8 consecutive cases with ODM were assessed.RESULTS: The ODMs in all cases (100%) presented similar IR -AF, SW -AF, and FA findings. On IR -AF images, ODMs showed outstanding hyper-AF with well-defined outline. On SW-AF images, the area of ODMs presented as hypo-AF. FA images revealed the leaking retinal telangiectasia on the surface of the ODMs. On SD-OCT images in 8 cases (100%), the ODMs were sloped with highly reflective surface, which were disorganized retina and optic nerve layers. In 7 cases (87.5%), peripapillary choroids were involved. The melanocytomas of 8 cases (100%) presented as optically empty spaces. Vitreous seeds were found in one case (12.5%).CONCLUSION: IR -AF imaging may provide a new modality to evaluate the pathologic features of ODMs, and together with SW-AF imaging, offers a new tool to study biological characteristics associated with ODMs. SD-OCT is a valuable tool in delimitating the tumor extension and providing morphological information about the adjacent retinal tissue.