Influence of Different Doses of Rosuvastatin on Levels of Serum C-reactive Protein,Uric Acid and Blood Lipid of Patients with Acute Coronary Syndrome

Objective To observe the influence of different doses of Rosuvastatin on levels of serum C-reactive protein( CRP),uric acid( UA) and blood lipid of patients with acute coronary syndrome( ACS). Methods A total of 48 patients with ACS were randomly divided into group A and B( n = 24). Based on expanding coronary arteries and improving the peripheral circulation,group A was treated with 5 mg /d Rosuvastatin orally,and group B was treated with 10 mg /d Rosuvastatin orally. After treatment for 8 weeks in the two groups,levels of CRP,UA and blood lipid were detected by extracting the venous blood,and adverse reactions were observed. Results Compared with those before treatment in the same group,levels of CRP,UA,total cholesterol( TC),triglyceride( TG) and low density lipoprotein cholesterol( LDL-C) were significantly lower,and high density lipoprotein cholesferol( HDL-C) level was significantly higher after treatment( P 0. 05); there were no significantly differences in levels of CRP,UA and blood lipid in the two groups before treatment( P 0. 05); there were no significantly differences in levels of CRP,UA,TC and LDL-C in the two groups after treatment( P 0. 05),the TG level in group B was significantly lower than that in group A( P 0. 05), while the HDL-C level in group B was significantly higher than that in group A( P 0. 05). There was no severe adverse reaction in the two groups. Conclusion Rosuvastatin can effectively improve the levels of serum CRP,UA and blood lipid,and 10 mg /d Rosuvastatin may achieve better effect.