Inhibited autophagy may contribute to heme toxicity in cardiomyoblast cells.

Alexandra Gyongyosi,Kitti Szoke,Ferenc Fenyvesi,Zsolt Fejes,Ildiko Beke Debreceni,Bela Nagy,Arpad Tosaki,Istvan Lekli

Biochemical and Biophysical Research Communications（2019）

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摘要

Several groups have demonstrated that induction of heme-oxygenase-1 (HO-1) could protect the myocardium against ischemic events; however, heme accumulation could lead to toxicity. The aim of the present study was to investigate the role of autophagy in heme toxicity.

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关键词

Autophagy,Cardiomyocytes,Heme oxygenase-1,Heme,Toxicity

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