UHPLC-Q-TOF-MS/MS method based on four-step strategy for metabolites of hinokiflavone in vivo and in vitro.

Yuting Chen,Xue Feng,Luya Li,Xiaowei Zhang,Kewei Song,Xinpeng Diao,Yupeng Sun,Lantong Zhang

Journal of Pharmaceutical and Biomedical Analysis（2019）

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摘要

•The metabolites of hinokiflavone were first characterized.•A rapid and sensitive method was developed.•Glutamine conjugation and glycine conjugation were unique metabolic pathways of hinokiflavone.•The metabolic profiling of hinokiflavone was first inferred and summarized.

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关键词

UHPLC-Q-TOF-MS/MS,HF,HRMS,TOF,DBS,MMDF,IDA,MDF,NADPH,UDPGA,PBS,XIC,PIF,NLF,CMC-Na,PTFE,RDA reaction

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