The soluble epoxide hydrolase determines cholesterol homeostasis by regulating AMPK and SREBP activity

    Prostaglandins & Other Lipid Mediators, pp. 30-39, 2016.

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    Abstract:

    Abstract Inhibition or deletion of the soluble epoxide hydrolase (sEH) has been linked to reduced cholesterol and protection against atherosclerosis. This study set out to identify sEH substrate(s) or product(s), altered in livers from sEH −/− mice that contribute to these beneficial effects. In livers and isolated hepatocytes, deleti...More

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