OX40 stimulation and PD-L1 blockade synergistically augment HBV-specific CD4 T cells in patients with HBeAg-negative infection.

Felix Johannes Jacobi,Katharina Wild,Maike Smits,Katharina Zoldan,Benedikt Csernalabics,Tobias Flecken,Julia Lang, Philipp Ehrenmann,Florian Emmerich,Maike Hofmann,Robert Thimme,Christoph Neumann-Haefelin,Tobias Boettler

Journal of Hepatology（2019）

引用 61|浏览21

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摘要

•OX40 (CD134) and PD-1 are strongly expressed on HBV-specific CD4 T cells ex vivo.•The HBV-specific CD4 T cells predominantly target the polymerase and core proteins.•Combined OX40 stimulation and PD-L1 blockade functionally augment HBV-specific CD4 T cells.

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关键词

Viral hepatitis,Antiviral immunity,Immunotherapy,Follicular T helper cells,Th1 cells,Cytokines

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