E3 ubiquitin ligases in B-cell malignancies.
Cellular Immunology(2019)
摘要
•The Proteasome ubiquitylation System is deregulated in a variety of B-cell cancers.•E3 ligase and substrate pairings in malignant B-cell cancer contribute to the initiation and maintenance of tumorigenesis.•Understanding the mechanism of specific E3 ligases will help the development of potential therapeutic targets.
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