Epigenetic marks of prenatal air pollution exposure found in multiple tissues relevant for child health.

Christine Ladd-Acosta,Jason I Feinberg,Shannon C Brown,Frederick W Lurmann,Lisa A Croen,Irva Hertz-Picciotto,Craig J Newschaffer,Andrew P Feinberg,M Daniele Fallin,Heather E Volk

Environment International（2019）

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摘要

•Prenatal air pollutant exposure is associated with neonate DNA methylation changes.•Increased prenatal ozone exposure associates with global losses of methylation.•Locus-specific air pollutant methylation changes occur in placenta and cord blood.•Some locus-specific methylation changes are sex-specific.

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关键词

ASD,DNAm,DMR,EARLI,NO2,O3,SVA

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