Neuregulin1 attenuates cognitive deficits and hippocampal CA1 neuronal apoptosis partly via ErbB4 receptor in a rat model of chronic cerebral hypoperfusion.

Yue Hei,Rong Chen, Xingang Mao,Jiancai Wang,Qianfa Long,Weiping Liu

Behavioural Brain Research（2019）

引用 21|浏览8

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摘要

•NRG1 could improve cognitive function in rats with CCH.•NRG1 could attenuate neuronal loss and apoptosis in hippocampal CA1 subarea in rats with CCH.•ErbB4 is activated and involved in the NRG1′ protective effects in rats with CCH.

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关键词

Neuregulin1,ErbB4,Chronic cerebral hypoperfusion,Neuronal apoptosis,Morris water maze,Radial arm water maze

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