Endemic Zika virus transmission: implications for travellers.

In 2016, a Zika virus epidemic swept across the Americas and resulted in the declaration of a Public Health Emergency of International Concern because of the potentially devastating consequences of congenital infection.1Rasmussen SA Jamieson DJ Honein MA Petersen LR Zika virus and birth defects—reviewing the evidence for causality.N Engl J Med. 2016; 374: 1981-1987Crossref PubMed Scopus (1341) Google Scholar, 2WHOWHO statement on the first meeting of the International Health Regulations (2005) (IHR 2005). Emergency Committee on Zika virus and observed increase in neurological disorders and neonatal malformations.http://www.who.int/news-room/detail/01-02-2016-who-statement-on-the-first-meeting-of-the-international-health-regulations-(2005)-(ihr-2005)-emergency-committee-on-zika-virus-and-observed-increase-in-neurological-disorders-and-neonatal-malformationsDate: 2016Date accessed: November 12, 2018Google Scholar Globally, Zika virus transmission occurs at a much lower level today than in 2016; however, cases have been reported in 2017 and 2018 in Africa and India, and serological studies suggest nearly 10% of children younger than 5 years in Indonesia have evidence of Zika virus infection.3Sassetti M Ze-Ze L Franco J et al.First case of confirmed congenital Zika syndrome in continental Africa.Trans R Soc Trop Med Hyg. 2018; 112: 458-462Crossref PubMed Scopus (20) Google Scholar, 4Saxena SK Kumar S Sharma R Maurya VK Dandu HR Bhatt ML Zika virus disease in India—update October 2018.Travel Med Infect Dis. 2018; (published online Nov 3.)DOI:10.1016/j.tmaid.2018.10.022PubMed Google Scholar, 5Sasmono RT Dhenni R Yohan B et al.Zika virus seropositivity in 1–4-year-old children, Indonesia, 2014.Emerg Infect Dis. 2018; (published online Sept 24.)DOI:10.3201/eid2409.180582Crossref PubMed Scopus (24) Google Scholar Better international surveillance for Zika virus and Zika-associated birth defects is needed to appropriately counsel pregnant women, partners of pregnant women, and reproductive-aged couples living in or travelling to Zika virus-endemic areas.6US Centers for Disease Control and PreventionZika travel information.https://wwwnc.cdc.gov/travel/page/zika-travel-informationDate: 2018Date accessed: November 12, 2018Google Scholar In The Lancet Infectious Diseases, Henrik Salje and colleagues7Salje H Tamrakar S Lowe S et al.Long-term circulation of Zika virus in Thailand: an observational study.Lancet Infect Dis. 2018; (published online Feb 27.)http://dx.doi.org/10.1016/S1473-3099(18)30718-7Google Scholar compare the age distribution of confirmed Zika virus disease cases in Thailand with that during the Colombian Zika virus outbreak, and with the historical age distribution of dengue virus in Thailand.8Pacheco O Beltran M Nelson CA et al.Zika virus disease in Colombia—preliminary report.N Engl J Med. 2016; (published online Jun 15.)DOI:10.1056/NEJMoa1604037Crossref Scopus (158) Google Scholar Although serosurveys typically establish levels of population immunity, cross-reactivity with other flaviviruses limits use of this method for Zika virus. Surveillance of confirmed, symptomatic cases, as presented by Salje and colleagues, can inform levels of population immunity, but might underestimate levels of population immunity from focal outbreaks. In settings with high levels of population immunity, recent cases would predominate in younger, previously unexposed populations, although exposure and health-care seeking can vary with age.7Salje H Tamrakar S Lowe S et al.Long-term circulation of Zika virus in Thailand: an observational study.Lancet Infect Dis. 2018; (published online Feb 27.)http://dx.doi.org/10.1016/S1473-3099(18)30718-7Google Scholar Use of confirmed symptomatic cases to draw inferences about population immunity assumes that immunity is long lasting, protective of clinical disease, symptomatic attack rates are similar across age groups, and sufficient numbers in all age groups were tested. Based on the age distribution of cases, Thailand might not have had sufficient levels of Zika virus transmission to yield widespread durable population immunity. Although the numbers tested in each age group are not clear, 368 symptomatic Zika virus infections in Thailand were confirmed from January 2016 to December 2017, from 29 of the 76 provinces. By contrast with dengue virus, where cases among children younger than 10 years are over-represented, with about four-fold more cases compared with the underlying population in that age group, the proportion of Zika virus cases in children younger than 10 years in Thailand was essentially identical to the underlying population. The age distribution of symptomatic Zika virus cases in Thailand in a setting of endemic transmission was similar to the age distribution observed in Colombia during the Zika virus epidemic, with those aged 21–30 years over-represented in both women and men, suggesting that many individuals of reproductive age in Thailand did not have immunity to Zika virus.7Salje H Tamrakar S Lowe S et al.Long-term circulation of Zika virus in Thailand: an observational study.Lancet Infect Dis. 2018; (published online Feb 27.)http://dx.doi.org/10.1016/S1473-3099(18)30718-7Google Scholar This absence of immunity has implications for the risk of Zika-associated birth defects. Zika virus infection during pregnancy can cause serious defects of the brain and eye, and has been linked to neurodevelopmental disabilities.9Rice ME Galang RR Roth NM et al.Vital signs: Zika-associated birth defects and neurodevelopmental abnormalities possibly associated with congenital Zika virus infection—U.S. territories and freely associated states, 2018.MMWR Morb Mortal Wkly Rep. 2018; 67: 858-867Crossref PubMed Scopus (141) Google Scholar, 10Hoen B Schaub B Funk AL et al.Pregnancy outcomes after ZIKV Infection in French territories in the Americas.N Engl J Med. 2018; 378: 985-994Crossref PubMed Scopus (207) Google Scholar The findings from Thailand underscore the ongoing risk to men and women of reproductive age living in endemic settings, and have important implications for travellers to areas with any Zika virus transmission. Although immunity to Zika virus is anticipated after infection, the duration of immunity is unknown. Reliable tests for immunity with high sensitivity and specificity are not yet readily available. Counselling about the risk of infection for residents and travellers is fraught with uncertainty. Lessons can be learned from the successful prevention of congenital rubella syndrome, achieved through widespread availability of an effective vaccine, universal immunisation of young children, and implementation of systems to identify and vaccinate adults without evidence of immunity.11Orenstein WA Bart KJ Hinman AR et al.The opportunity and obligation to eliminate rubella from the United States.JAMA. 1984; 251: 1988-1994Crossref PubMed Scopus (75) Google Scholar Zika virus will remain a threat to healthy pregnancies until an effective Zika virus vaccine and reliable tests of immunity are readily available. Until then, we expect to continue to see increased numbers of adverse birth outcomes in countries with Zika virus transmission. Monitoring for adverse birth outcomes requires robust birth defects surveillance. The same serious birth defects of the brain and eye that can be caused by Zika virus affected about 0·16% of liveborn infants in the USA before the introduction of Zika virus to the Americas, but there was a more than 30-fold increased risk of these birth defects among pregnancies with laboratory evidence of possible Zika virus infections.9Rice ME Galang RR Roth NM et al.Vital signs: Zika-associated birth defects and neurodevelopmental abnormalities possibly associated with congenital Zika virus infection—U.S. territories and freely associated states, 2018.MMWR Morb Mortal Wkly Rep. 2018; 67: 858-867Crossref PubMed Scopus (141) Google Scholar Infants with congenital Zika syndrome have been reported from Thailand both among pregnancies with laboratory-confirmed Zika virus infection and when diagnosis did not occur until after delivery. Most of the countries and territories affected by Zika virus are without adequate birth defects surveillance necessary to identify and monitor cases of Zika-associated birth defects, limiting international understanding of the full effect of Zika virus. Pregnant women should carefully consider the risk for Zika virus when planning travel, because decisions about travel are one effective strategy to prevent mosquito-borne transmission of Zika virus. However, determining the risk posed by Zika virus can be hampered by delays in identifying and reporting Zika virus cases—an infection that often occurs with mild or no symptoms. Travellers, particularly pregnant women or their partners, should be counselled about possible risks and should be aware that we often do not have real-time regional epidemiological data on Zika virus transmission, and travel guidance should consider the limitations of available epidemiological data. Thailand, and presumably many countries in southeast Asia, have experienced variable transmission across many regions. The findings from Salje and colleagues regarding the distribution of symptomatic persons in Thailand heighten concerns there might be lower levels of population immunity than expected and therefore an ongoing risk to pregnant women travelling to or living in endemic settings.7Salje H Tamrakar S Lowe S et al.Long-term circulation of Zika virus in Thailand: an observational study.Lancet Infect Dis. 2018; (published online Feb 27.)http://dx.doi.org/10.1016/S1473-3099(18)30718-7Google Scholar We declare no competing interests. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the US Centers for Disease Control and Prevention. Long-term circulation of Zika virus in Thailand: an observational studyOur evidence shows that Zika virus has circulated at a low but sustained level for at least 16 years, suggesting that Zika virus can adapt to persistent endemic transmission. Health systems need to adapt to cope with regular occurrences of the severe complications associated with infection. Full-Text PDF