Exploring substituent diversity on pyrrolidine-aryltriazole iminosugars: Structural basis of β-glucocerebrosidase inhibition.

•Dihydroxy pyrrolidine-aryltriazoles are selective inhibitors of β-glucocerebrosidase.•The substitution pattern of the phenyl moiety influences the inhibition.•Pyrrolidine-aryltriazoles act as chaperones of mutant β-glucocerebrosidase.•First co-crystal structure of a pyrrolidine-iminosugar with β-glucocerebrosidase.