Australeols A-F, neuroprotective meroterpenoids from Ganoderma australe.

Six new meroterpenoids, australeols A-F (1-6), together with nineteen known compounds (7-25), were isolated from the fruiting bodies of Ganoderma australe. Their structures including absolute configurations were assigned by using spectroscopic methods, CD comparison, and X-ray crystallography analysis. Biological evaluation reveals that compounds 13, (-)-19, and 23 exhibit potent neuroprotective activities in glutamate-stimulated SH-SY5Y cells.