Analysis of postoperative radiotherapy effect in the treatment of patients with N_2 non-small cell lung cancer at IIIA period and its prognostic factors

Objective To explore the curative effect and prognostic factors of radiotherapy in the treatment of patients with N2 non-small cell lung cancer(NSCLC) at ⅢA period.Methods The clinical data of 195 patients with N2 NSCLC were retrospectively analyzed,and 5-year survival was considered as the prognostic index.Results The survival rates of 1 year,3 years and 5 years survival rates were respectively 58.5%,29.7% and 19.0%.The results of multiple factors COX regression showed that the independent risk factors included gross tumor volume(OR=2.840),T grades(OR=1.923),and N2 metastasis groups(OR=2.672).N2 amicula integrity(OR=0.316) and radiotherapy dose(OR=0.270) were protective factors.Conclusion The 5-year survival rate is a little lower in patients with N2 NSCLC with poor prognosis.The independent risk factors include gross tumor volume,high T-grade,N2 metastasis groups,N2 amicula imperfect and low radiation dose.