Protective effect of antioxidant Tempol on cardiac stem cells in chronic pressure overload hypertrophy.

Restoration of functional efficiency of CSCs by antioxidants signifies the role of oxidative stress in deterioration of stem cell attributes in the hypertrophic heart. The observations envisage the use of antioxidants as adjuvant medication for maintaining a healthy stem cell population, which can in-turn prevent progressive cardiac remodelling, a major determinant of cardiac failure.