Abstract 882: Serum Hsp27 levels may serve as a prognostic biomarker in patients with localized breast cancer: A preliminary report

Although there exist some prognostic biomarkers (eg, CA 15-3) for evaluation of responses to therapy in metastatic breast cancer patients, there is no reliable biomarker for early stage breast cancer patients. Heat shock protein 27 (Hsp27) has been reported as elevated in many human cancers of carcinoma origin. We have simultaneously tested serum levels of Hsp27 and CA 15-3 by specific ELISA in 49 untreated breast cancer patients (age→52.77±1.28) with early to locally advanced disease [Stage I (n=21), IIA and B (n=21), IIIA, B and C (n=7)] and 37 female controls (age→50.86±1.60). Hsp27 levels were significantly (p Work supported by ACS RSG-06-266-01-LIB awarded to A. De Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 882.