Simultaneous sequential monitoring of efficacy and safety led to masking of effects.

Rik van Eekelen,Esther de Hoop,Ingeborg van der Tweel

Journal of Clinical Epidemiology（2016）

引用 2|浏览17

暂无评分

摘要

Monitoring two correlated outcomes, given that both are essential for early trial termination, leads to masking of true effects. Careful consideration of scenarios must be taken into account when designing sequential trials. Simulation results can help guide trial design.

查看译文

关键词

Randomized controlled trial,Simulation,Sequential designs,Multiple outcomes,O'Brien-Fleming,Triangular Test

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要